Sex-Specific Associations Between Changes in Triglyceride-Glucose (TyG) Index and Risk of Chronic Kidney Disease: A Cohort Study of Young and Middle-Aged Adults.

ABSTRACT: Background/Objectives: The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance associated with chronic kidney disease (CKD). The effect of TyG index changes on the development of CKD in young adults remains unclear. Methods: We studied 353,140 Korean adults aged 18-49 years who underwent at least two health screenings. The TyG index changes between visits were categorized into quintiles. Incident CKD was defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m² or proteinuria. Cox proportional hazards models were used to estimate the hazard ratios (HRs) for CKD risk. Results: Over 2.74 million person-years, 18,857 men and 13,394 women developed CKD. In the fully adjusted models, men in the highest quintile of TyG index

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC12472455 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature