Antihypertensive Effect of a Self-Microemulsifying System Obtained from an Ethanolic Extract of <i>Heliopsis longipes</i> Root in Spontaneously and L-NAME-Induced Hypertensive Rats.

ABSTRACT: Arterial hypertension is a major contributor to cardiovascular disease, the leading cause of death globally. Previously, our research group has demonstrated that both organic extracts from Heliopsis longipes roots and affinin-its principal bioactive compound-induce vasodilation and exert antihypertensive effects in L-NAME-induced hypertensive rats. However, the poor water solubility of these extracts limits their oral administration and dosing. To address this limitation, a self-microemulsifying drug delivery system (HL-SMDS) was developed from an ethanolic extract of H. longipes root to enhance its aqueous solubility and oral bioavailability. This study evaluated the antihypertensive efficacy of HL-SMDS in spontaneously hypertensive and L-NAME-induced hypertensive rat models

SUBMITTER: Marrero-Morfa D 

PROVIDER: S-EPMC12472576 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature