Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis.

ABSTRACT: Background and Aims: Numerous clinical and observational studies have examined the role of vitamin D in glycemic control and metabolic regulation among diabetic patients, but findings remain inconsistent. This meta-analysis aimed to assess the effects of vitamin D supplementation on glycosylated hemoglobin (HbA1c%), HOMA-IR, HOMA-β, LDL cholesterol, total cholesterol, triglycerides, fasting insulin, fasting plasma glucose, C-reactive protein, and the likelihood of reversion to normoglycemia in prediabetic individuals. Methods: A comprehensive search of multiple databases was performed using keywords including "diabetes mellitus," "type 2 diabetes," "vitamin D supplementation," and "VD supplementation." Twenty studies met the inclusion criteria. Results: Vitamin D suppl

SUBMITTER: Bruna-Mejias A 

PROVIDER: S-EPMC12472623 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature