Species-Specific Stress Responses to Selenium Nanoparticles in <i>Pseudomonas aeruginosa</i> and <i>Proteus mirabilis</i>.

ABSTRACT: Urinary tract infections (UTIs) remain a major global health concern, with rising antimicrobial resistance prompting the search for alternative therapies. Selenium nanoparticles (Se NPs) are promising antimicrobial agents due to their unique physicochemical properties and ability to disrupt bacterial physiology. This study evaluated the antibacterial efficacy of Se NPs against four uropathogens and conducted comparative proteomic analyses to elucidate stress responses. Enumeration assays showed that Se NPs effectively inhibited bacterial growth, with Pseudomonas aeruginosa being the most susceptible and Proteus mirabilis the most resistant. Microscopy revealed Se NP-induced membrane rupture and cellular deformation across all species. Proteomic and bioinformatic analyses show

SUBMITTER: Sung K 

PROVIDER: S-EPMC12472632 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature