Differential Gene Expression and Protein-Protein Interaction Networks in Bovine Leukemia Virus Infected Cattle: An RNA-Seq Study.

ABSTRACT:

Introduction

Bovine leukemia virus is a single-stranded RNA virus that targets B cell CD5⁺ lymphocytes in cattle. Only a tiny percentage of individuals develop malignant lymphoproliferative disorders, while most remain healthy carriers or experience persistent lymphocytosis. The exact mechanisms leading to lymphoma development are complex and not fully understood. RNA-seq analysis of cows' peripheral blood leukocytes (PBLs) with and without Bovine leukemia virus (BLV) antibodies was conducted to gain a deeper understanding of molecular events beyond BLV infection.

Method

Eighteen samples were selected, and their RNA was sequenced. For gene expression analysis and protein-protein network interactions, three groups were selected, including healthy negative samples (

SUBMITTER: Gonzalez-Mendez AS 

PROVIDER: S-EPMC12472682 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature