Poloxamer-Based Biomaterial as a Pharmaceutical Strategy to Improve the Ivermectin Performance.

ABSTRACT: Background: Poloxamers are promising biomaterials for drug delivery applications due to their ability to enhance biopharmaceutical properties. Methods: This study focused on designing solid dispersions of ivermectin using poloxamer 407 by the fusion method and evaluating how variables of synthesis affect the polymer's behavior and the resulting biopharmaceutical properties of ivermectin. Poloxamer 407 was selected based on a solubility test of preformulation studies. Initially, eight formulations were developed using different synthesis conditions, including polymer proportion, cooling gradient, and final process temperature. These were assessed by several characterization studies. Finally, saturation solubility dissolution profiles and in vitro drug release were also evaluat

SUBMITTER: Mezzano BA 

PROVIDER: S-EPMC12472695 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature