Dose-Dependent Effect of Tilmicosin Residues on <i>erm</i>A Rebound Mediated by <i>IntI</i>1 in Pig Manure Compost.

ABSTRACT: The impact of varying antibiotic residue levels on antibiotic resistance gene (ARG) removal during composting is still unclear. This study investigated the impact of different residue levels of tilmicosin (TIM), a common veterinary macrolide antibiotic, on ARG removal during pig manure composting. Three groups were used: the CK group (no TIM), the L group (246.49 ± 22.83 mg/kg TIM), and the H group (529.99 ± 16.15 mg/kg TIM). Composting removed most targeted macrolide resistance genes (MRGs) like ereA, ermC, and ermF (>90% removal), and reduced ermB, ermX, ermQ, acrA, acrB, and mefA (30-70% removal). However, ermA increased in abundance. TIM altered compost community structure, driving succession through a deterministic

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12472723 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature