Characterization of Prophages and Their Genetic Cargo in Clinical <i>M. abscessus</i> Isolates.

ABSTRACT: Limited data exist regarding lysogenic phages carried by M. abscessus, as well as regarding their roles played in diseases. Strains identified as M. abscessus from patients were collected. Prophages, virulence factors, and antibiotic resistance genes present in genomes were predicted, and correlations between prophages, virulence factors, antibiotic resistance genes, and clinical patient prognoses were analyzed. A total of 145 prophage sequences were detected in 56 M. abscessus strains. Prophages contained more virulence factors and antibiotic resistance genes, compared to known mycobacteriophages. The average sequence similarity among prophage sequences from a single patient was significantly higher than that among prophages from different patients or between prophage

SUBMITTER: Luan S 

PROVIDER: S-EPMC12472911 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature