Semi-Synthesis and Biological Evaluation of Novel Sinomenine Derivatives.

ABSTRACT: Sinomenine has long been known as an anti-inflammatory drug, while poor efficiency and large-dose treatment had limited its further application. Five novel sinomenine 1-Br-4-cinnamic acid esters derivatives 2a-2e were designed and synthesized to improve its analgesic and anti-inflammatory activity. All synthesized sinomenine derivatives were structurally confirmed by NMR and ESI-MS. Molecular docking results showed that compounds 2a-2e had stable binding to the GBP5 protein. The compounds 2a-2e showed stable binding to the GBP5 protein by molecular docking Pre-preparing the druggability of compounds 2a-2e by ADEMT 3.0 showed that each derivative had similar druggability to sinomenine. The analgesic activity of compounds 2a-2

SUBMITTER: Wu M 

PROVIDER: S-EPMC12472971 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature