CGRP Suppresses Protective SiglecF^hi Neutrophil Development in Neonatal Group B <i>Streptococcus</i> Pneumonia.

ABSTRACT: Neonatal pneumonia, a leading cause of morbidity and mortality, is frequently caused by Group B Streptococcus (GBS). The mechanisms underlying protective immunity to this pathogen in the neonatal lung remain incompletely understood. Using a clinically relevant neonatal mouse model of GBS pneumonia, we investigated the immune mechanisms influencing disease severity. We demonstrate that neutrophils are effectively recruited to the lungs of infected neonates, but their phenotype differs with disease severity. In pups with moderate disease, we observe significant infiltration of SiglecF^hi neutrophils, a phenotype associated with enhanced phagocytic capacity and bacterial clearance. In contrast, pups with severe disease failed to develop SiglecF^hi neutrophils, resul

SUBMITTER: Lorga I 

PROVIDER: S-EPMC12473038 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature