A Comparative Study of Extended Gentamicin and Tobramycin Release and Antibacterial Efficacy from Palacos and Simplex Acrylic Cements.

ABSTRACT: Antibiotic-loaded bone cements (ALBCs) are used to prevent and treat periprosthetic joint infections (PJI). This study compares the in vitro release and antibacterial effectiveness of gentamicin from Palacos^® R+G and tobramycin from Simplex^® T. Standardized cylindrical specimens of Palacos^® R+G and Simplex^® T were incubated in phosphate-buffered saline. Antibiotic release was quantified using high-performance liquid chromatography (HPLC) over 14 and 42 days. Antibacterial efficacy was assessed using inhibition zone tests (IZT) against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli over 42 days. Palacos^® R+G exhibited a significantly higher and more sustained antibiotic release of gentamicin

SUBMITTER: Coraca-Huber D 

PROVIDER: S-EPMC12473054 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature