PH-Sensitive Naproxen Delivery via ZIF and Kaolin@ZIF Nanocarriers in 3D-Printed PLA-Gelatin Hydrogels.

ABSTRACT: This study presents a pH-responsive drug delivery platform, created based on naproxen-loaded zeolitic imidazolate frameworks (ZIF) and kaolin-ZIF (Kao@ZIF) nanocarriers embedded in a 3D-printed polylactic acid (PLA) scaffold coated with a gelatin hydrogel. The PLA discs were designed as structural tissue models to simulate localized drug release. Kaolin (Kao), a basic mineral in the kaolin group that includes halloysite, was selected as a chemically stable and biocompatible adsorbent to enhance ZIF integrity and system reliability. To address the concerns about the safety and reproducibility of nanoscale materials in biomedical applications, structurally stable ZIF and Kao@ZIF nanocarriers were synthesized and characterized using FT-IR, SEM-EDS, and LC-M/MS, measuring drug loading efficien

SUBMITTER: Cetin R 

PROVIDER: S-EPMC12473257 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature