Evaluation of Magnetization Transfer Contrast Sequences: Application to Monitor Age-Related Differences in Muscle Macromolecular Fraction.

ABSTRACT:

Background/objectives

Several sequences for magnetization transfer contrast (MTC) imaging are available, from indices of MTC ranging from quantitative magnetization transfer (qMT) that yields the macromolecular fraction to simple ratios of signal intensities with and without a magnetization transfer (MT) pulse. Aging muscle undergoes changes including an increase in fibrosis and adipose accompanied by fiber atrophy and loss. The objective is to evaluate five MTC sequences to study age-related differences in muscle tissue composition.

Methods

The lower leg (calf) of 15 young (8M/7F, 25.8 ± 3.7 years) and 9 senior subjects (5F/4M, 68.4 ± 3.3 years) was imaged with the following sequences: multi-offset qMT fit to the Ramani and Yarnykh models, single-offset qMT two-parameter fi

SUBMITTER: Crispin-Smith A 

PROVIDER: S-EPMC12473340 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature