Enhanced Efinaconazole Permeation and Activity Against <i>Trichophyton rubrum</i> and <i>Trichophyton mentagrophytes</i> with a Self-Nanoemulsifying Drug Delivery System.

ABSTRACT: Background: Onychomycosis responds poorly to topical therapy, and efinaconazole (EFN) has low aqueous solubility. Methods: This study aimed to develop a 10% w/w EFN self-nanoemulsifying system (SNEDDS) with improved solubility, permeation, antifungal activity, and stability. Excipients were screened by EFN saturation solubility. An MCT oil/Solutol HS 15/Labrafil M2125 CS SNEDDS (5/75/20, w/w) was optimized via a pseudo-ternary diagram. Characterization included droplet size, PDI, and zeta potential, morphology, and drug-excipient compatibility. Solubility was measured across pH. Permeation of EFN SNEDDS vs. EFN suspension was tested by Franz diffusion cells. Antifungal activity against Trichophyton rubrum and Trichophyton mentagrophytes</

SUBMITTER: Yun SW 

PROVIDER: S-EPMC12473344 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature