Pancreatic Cancer-Targeting Cascade Nanoamplifier Enables Self-Replenishing H₂O₂ Generation and Autophagy Disruption in Chemodynamic Therapy.

ABSTRACT: Background/Objectives: Conventional therapeutic strategies exhibit limited efficacy against pancreatic cancer, primarily due to its profoundly hypoxic tumor microenvironment and dense fibrotic stroma. Chemodynamic therapy (CDT) holds promise; however, its application in pancreatic cancer is restricted by insufficient endogenous hydrogen peroxide (H₂O₂) levels and the activation of protective autophagy in response to oxidative stress. Methods: To overcome these obstacles, we developed a tumor microenvironment-responsive, pancreatic cancer-targeted CDT nanoamplifier-H-MnO₂/GOX&CQ-iRGD-comprising a hollow mesoporous MnO₂ shell co-loaded with glucose oxidase (GOX) and chloroquine (CQ), and surface-functionalized with the tumor-penetrati

SUBMITTER: Yu J 

PROVIDER: S-EPMC12473349 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature