Selective Inhibition of <i>Yersinia enterocolitica</i> Type III Secretion by <i>Lindera obtusiloba</i> Extract and Cinnamtannin B1.

ABSTRACT: Background/Objectives: Selective inhibition of bacterial virulence factors is a promising strategy to convert pathogenic bacteria into non-pathogenic commensals, circumventing the challenge of antibiotic resistance. This approach enables the host immune system to eliminate virulence-attenuated pathogens. Methods: In this study, we evaluated the effects of Lindera obtusiloba Blume extract and cinnamtannin B1, the active component of the ethyl acetate fraction, on the type III secretion system (T3SS) of Yersinia enterocolitica. Results: The ethyl acetate fraction, at 100 mg/L, effectively suppressed all three T3SS components-the flagellar, Ysa, and Ysc T3SSs. Cinnamtannin B1, isolated from the ethyl acetate fraction through separation and identified through

SUBMITTER: Yoo JH 

PROVIDER: S-EPMC12473489 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature