Efficacy of <i>Phlomis crinita</i> Extract-Loaded Nanostructured Formulation in Accelerating Wound Healing.

ABSTRACT: Background/Objectives: Recent advancements in innovative drug delivery nanosystems have significantly impacted wound healing, particularly through the incorporation of natural products. This study aimed to develop and characterize a Phlomis crinita extract-loaded nanostructured formulation (PCE-NF) as a topical therapy for skin wounds. Methods: This study involved the incorporation of P. crinita extract in a nanoemulsion by the high-energy emulsification method. This formulation was subjected to physicochemical and biopharmaceutical characterization, and a physical stability study over 30 days. Biocompatibility, tolerability, and irritant effects were assessed, while the wound healing potential was evaluated using in vitro skin models of fibroblasts and keratino

SUBMITTER: Kosksi T 

PROVIDER: S-EPMC12473550 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature