Modeling and Design of Chitosan-PCL Bi-Layered Microspheres for Intravitreal Controlled Release.

ABSTRACT: Background/Objectives: Chronic retinal diseases usually require repetitive local dosing. Depending on factors such as dosing frequency, mode of administration, and associated costs, this can result in poor patient compliance. A better alternative involves using controlled-release drug delivery systems to reduce the frequency of intravitreal dosing and extend drug release. However, reaching the market stage is a time-consuming process. Methods: In this study, we employed two computational approaches to model and estimate the parameters governing the diffusion-controlled drug release from bi-layered microspheres. The case study involved microspheres composed of a chitosan core and a polycaprolactone (PCL) shell. The model drugs were bovine serum albumin and bevacizumab (an agen

SUBMITTER: Chacin Ruiz EA 

PROVIDER: S-EPMC12473585 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature