Development of Timed Release Vaginal Mucosal Cloprostenol for Farrowing Management in Sows.

ABSTRACT: Background/Objectives: Controlling the timing of farrowing to occur during working hours presents an opportunity to improve supervision and reduce piglet neonatal mortality. However, the use of non-therapeutic injectable drugs is often limited in commercial swine production. This study aimed to develop a cloprostenol vaginal mucosal delivery system for induction of farrowing. To achieve this, two vaginal tablets containing cloprostenol were formulated for simultaneous insertion: an immediate-release (IR) tablet and a delayed release (DR) tablet, the latter designed for a 6 h delay before release. Methods: In vitro release studies demonstrated that the IR tablet released 100% of the drug within 5 min, while the DR tablet, initiated release after four hours and achieved approxi

SUBMITTER: Uddin AM 

PROVIDER: S-EPMC12473592 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature