Fabrication and In Vitro Evaluation of LL37-Loaded Electrospun PHB/Collagen Nanofibers for Wound Healing.

ABSTRACT: Skin repair is essential in the treatment of burns and wounds. After an injury, the concept of tissue engineering emerges to restore skin function and facilitate wound healing. This field often involves the use of biodegradable and biocompatible materials as a primary scaffold for tissue regeneration. In this study, a PHB/Collagen wound dressing mat loaded with the antimicrobial peptide LL37 was developed via electrospinning. The polymer solutions were prepared by dissolving polyhydroxybutyrate (PHB) biopolymer extracted from Cereibacter sphaeroides, commercial PHB, and marine collagen in hexafluoroisopropanol (HFIP). The resulting nanofibers were characterized using Field-Emission Scanning Electron Microscopy (FE-SEM), Thermogravimetric Analysis (TGA), X-Ray Diffractometry (XRD), a

SUBMITTER: Sayaner Tascı BN 

PROVIDER: S-EPMC12473663 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature