Daunomycin Nanocarriers with High Therapeutic Payload for the Treatment of Childhood Leukemia.

ABSTRACT: Background/Objectives: Malignant neoplasms in children include leukemias. The main types are B-cell acute lymphoblastic leukemia (B-ALL) and acute myeloid leukemia (AML). Treatments are expensive, which is a particular problem in low-income countries. The main objective of this work was to develop specific nanosystems with small amounts of drug, allowing for affordable treatments. To this end, we designed ternary gold nanosystems (Au@16-Ph-16/DNA-Dauno) composed of daunomycin, a DNA biopolymer as a stabilizer, and the cationic surfactant gemini (TG) as a compacting agent for the DNA-daunomycin complex. Methods: Fluorescence, UV-visible, and CD spectroscopy, DLS and zeta potential, cell viability assays, TEM, AFM, and confocal microscopy were used to characterize and optimize

SUBMITTER: Giraldez-Perez RM 

PROVIDER: S-EPMC12473718 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature