Evolving Dynamics of Whole-Genome Influenza A/H3N2 Viruses Isolated in Cameroon.

ABSTRACT: Background: Since 2023, Cameroon has recorded numerous cases of seasonal influenza caused by the A/H3N2 subtype, which is the strain most commonly encountered worldwide in 2024. Methods: To describe the evolutionary dynamics of influenza A/H3N2 viruses, whole genome sequencing was performed using the Oxford Nanopore Technologies sequencing platform and the SQK-LSK109, EXP-NBD196 reagent kit (Oxford Nanopore Technologies, catalog no. SQK-LSK109). Subsequently, mutational analysis was performed on the 8 genes of the H3N2 influenza strains isolated between 2023 and 2024 in Cameroon by aligning our protein sequences with the reference sequences recommended by the WHO in the northern hemisphere during the 2023-2024 influenza season using MEGA 11 software. The trimeric and tetramer

SUBMITTER: Tsafack DT 

PROVIDER: S-EPMC12473741 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature