Biomimetic Filler Strategy for Two-Step Universal Dental Adhesives Using PA-ACP/MSN: Effects on Wettability, Immediate Microtensile Bond Strength, and Cytocompatibility.

ABSTRACT: This study evaluated a biomimetic filler strategy for two-step universal dental adhesives by integrating amine-functionalized mesoporous silica nanoparticles (MSNs) loaded with polyacrylic acid-stabilized amorphous calcium phosphate (PA-ACP) into the primer phase. MSNs were synthesized and characterized by FTIR, N₂ sorption (BET), and HRTEM to confirm structural integrity and effective PA-ACP loading. Two commercial adhesives (G2 Bond and OptiBond eXTRa) were modified by incorporating different volumes fractions (10, 15, 20 vol%) of PA-ACP/MSN. Wettability (contact angle), microtensile bond strength (μTBS), and cytotoxicity (indirect MTT assay using human periodontal ligament fibroblasts, HPLFs) were assessed. The results demonstrated that incorporating up to 15 vol% PA-ACP/MSN

SUBMITTER: Alnakib Y 

PROVIDER: S-EPMC12473806 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature