Amino Compound-Synthesized Gold Nanoparticles for SARS-CoV-2 Antigen Delivery.

ABSTRACT: Background: Gold nanoparticles (AuNPs) are a promising platform for vaccine antigen delivery due to their ability to stimulate both innate and adaptive immune responses. These effects depend strongly on physicochemical properties such as size, polydispersity, morphology, and surface charge, which are in turn determined by the synthesis method. While amino acids are often used as capping agents for AuNPs, their direct use as both reducing and stabilizing agents has been rarely investigated. Objectives: This study aimed to establish an ultrasound-assisted method for synthesizing AuNPs using amino compounds as both reducing and stabilizing agents, and assess their physicochemical characteristics, antigen-binding capacity, and immunogenicity. Methods: AuNPs were synthesize

SUBMITTER: Rego LS 

PROVIDER: S-EPMC12473889 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature