Redox-Responsive π-Conjugated Prodrug Nanoassemblies for Cancer Chemotherapy.

ABSTRACT: Background: Redox-responsive prodrug nanoassemblies (NAs) have been extensively utilized in precise cancer therapy. But there is no research shedding light on the impacts of the π-π stacking interactions on the self-assembly capacity of redox-responsive prodrugs and the in vivo delivery fate of NAs. Methods: Three structurally engineered doxorubicin (DOX) prodrugs (FAD, FBD, and FGD) were developed through α-, β-, and γ-positioned disulfide linkages with π-conjugated Fmoc moieties. The NAs were comprehensively characterized for their self-assembly kinetics, redox-responsive drug release profiles, and physicochemical stability. Biological evaluations included cellular uptake efficiency, in vivo pharmacokinetics, and antitumor efficacy in tumor-bearing mouse models. Results<

SUBMITTER: Liu S 

PROVIDER: S-EPMC12473931 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature