In Vivo Antihypertensive and Ex Vivo Vasodilatory Studies of Taxifolin.

ABSTRACT: Background: Hypertension is a leading cause of cardiovascular morbidity and mortality. Taxifolin has shown cardiovascular benefits, but its antihypertensive mechanisms remain poorly defined. This study aimed to comprehensively elucidate the molecular mechanisms underlying Taxifolin's blood pressure-lowering effects by integrating network pharmacology, molecular docking, ex vivo functional studies, and in vivo validation. Methods: Network pharmacology and molecular docking prioritized targets. Ex vivo thoracic aortas were obtained from healthy male Sprague-Dawley (SD) rats, and rings (3-4 mm) were prepared for vasorelaxation studies. Pathway-specific inhibitors, Western blotting, and ELISA were used to investigate mechanisms. In vivo, spontaneously hypertensive rats (SHRs) rec

SUBMITTER: Wang X 

PROVIDER: S-EPMC12473947 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature