Microenvironmental pH-Modulated Dissolution of Albendazole Layered on Tartaric Acid Starter Pellet Cores.

ABSTRACT: Background/Objectives: To improve the therapeutic efficacy of albendazole (ABZ) for ileocolonic diseases, its low solubility at higher pH levels should be enhanced. Organic acids have been widely used as pH modifiers to improve the solubility of weakly basic drugs. To achieve an adequate effect of the acidic microenvironmental pH during the drug release, pH modifiers should not leach out from the formulation. In the present work, we aimed to demonstrate that 100% tartaric acid pellets (TAP) can be used as pH-modifier cores, providing an acidic microenvironmental pH to enhance the solubility of albendazole at a higher pH. Methods: This study develops multilayer-coated pellets using TAP as starter cores in a bottom-spray-configured fluidized bed apparatus. The drug-layered TAP

SUBMITTER: Vlahovic K 

PROVIDER: S-EPMC12474003 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature