Effects of Novel Mutations in the <i>LEPR</i> Gene on Litter Size in Gobi Short Tail Sheep and Sonid Sheep.

ABSTRACT: Increasing the litter size in sheep is a primary objective in breeding programs, driving sustained interest in identifying candidate functional genes and molecular markers associated with fecundity. The known FecD mutation in the LEPR gene has been shown to regulate reproductive traits by influencing the ovulation rate of Davisdale sheep. However, the relationship between single-nucleotide polymorphisms (SNPs) in the LEPR and litter size remains unknown in Gobi short tail sheep and Sonid sheep. In this research, we found one novel variant and thirteen known variants through direct sequencing in Sonid sheep and Gobi short tail sheep and performed an association study in a large-scale population. The association analysis identified two SNPs (c.240C>T (rs159694506) and c.279C>T

SUBMITTER: Yang S 

PROVIDER: S-EPMC12474046 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature