Viral Burden of Respiratory Syncytial Virus and Viral Coinfections as Factors Regulating Paediatric Disease Severity.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections (ARIs) in children. However, the clinical impact of RSV co-infection with other respiratory viruses remains unclear. This study investigates the frequency and clinical outcomes of RSV infections in a large paediatric cohort.

Methods

Paediatric patients with RSV-positive respiratory samples admitted to Bambino Gesù Children's Hospital between January 2022 and April 2024 were analysed.

Results

Within 17,259 respiratory samples from 9877 paediatric patients, 952 (9.6%) were RSV-positive. Among these, 637 patients with ARI were included. RSV affected the lower respiratory tract in 549 cases (86.2%) and the upper tract in 88 (13.8%) cases. RSV mono-infection was found in 286 (44

SUBMITTER: Di Maio VC 

PROVIDER: S-EPMC12474089 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature