The Viremic Phase and Humoral Immune Response Against African Horse Sickness Virus That Emerged in Thailand in 2020.

ABSTRACT: African horse sickness (AHS), a life-threatening disease caused by African horse sickness virus serotype 1 (AHSV-1), emerged in Thailand in February 2020 with 607 cases and a 93% fatality rate. The outbreak was mitigated by vector control and a live attenuated virus (LAV) vaccine. Information regarding viremia and immunity after infection and vaccination during outbreaks are essential for controlling disease transmission. This study evaluated these parameters in 15 infected naïve horses and 11 vaccinated horses during the 2020 outbreak. Whole blood was collected and subjected to RT real-time PCR to detect viremia up to 52 weeks post-infection. ASHV-specific antibodies were accessed by blocking ELISA until 37 weeks post-vaccination. In both groups, viremia appeared in the first week and las

SUBMITTER: Pipitpornsirikul P 

PROVIDER: S-EPMC12474096 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature