Toxicological Impacts of Polypropylene Nanoparticles Similar in Size to Nanoplastics in Plastic-Bottle Injections on Human Umbilical Vein Endothelial Cells.

ABSTRACT: Microplastic and nanoplastic (MNP) particles have been observed in various human organs. However, polypropylene (PP), one of the top three most commonly detected types of MNPs in terms of quantity, is also present in injections given for the infusion treatment of diseases, and there is a considerable knowledge gap concerning its adverse effects on the human cardiovascular system. In this study, we used commercial PP particles (500 nm), similar in size to nanoplastics (NPs) present in injections and greater than or equal in concentration to NPs in the blood of healthy individuals, as the experimental dose to study their toxicological effects on human umbilical vein endothelial cells. The results revealed that PP particles at 35 μg/mL, equivalent to 20 times the concentration of blood, reduc

SUBMITTER: Wang J 

PROVIDER: S-EPMC12474203 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature