Role of the Gene <i>tri14</i> in Biosynthesis of the Trichothecene Toxin Harzianum A in <i>Trichoderma arundinaceum</i>.

ABSTRACT: Trichothecenes are a family of toxic metabolites produced by multiple fungal species. All trichothecene analogs include an epoxide-containing tricyclic structure known as 12,13-epoxytrichothec-9-ene (EPT) but differ by the presence, absence and types of substituents attached to EPT. Among the 21 known genes associated with trichothecene biosynthesis, tri14 is one of only three that are universally found in all trichothecene-producing fungi. Recent studies have revealed that the tri14-encoded protein, Tri14, enhances the biosynthetic reaction that forms EPT, a reaction previously thought to occur spontaneously. In our study, we assessed the impact of tri14 deletion on the biology of Trichoderma arundinaceum, a producer of the trichothecene harzianum A (HA). The r

SUBMITTER: Martinez-Reyes N 

PROVIDER: S-EPMC12474229 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature