Characterization of the Chemical Composition, Cytotoxicity, and Metabolomic Effects of PM_2.5 in a Plateau City, China.

ABSTRACT: The health impacts of atmospheric fine particulate matter (PM_2.5) in plateau regions have attracted concerns, along with local population growth and rapid urbanization. This study collected PM_2.5 samples at summer and winter in Xining, a city located in the northeastern Tibetan Plateau. The chemical composition of PM_2.5 and its cytotoxicity on human lung epithelial cells (A549) are characterized, and composition-cytotoxicity correlation is discussed. The toxic mechanisms of PM_2.5 in different seasons were further investigated through metabolomic analysis using high-resolution mass spectrometry. The average PM_2.5 mass concentration in Xining during winter was 2.10 times higher than that during summer. The carbonaceous components in PM

SUBMITTER: Li M 

PROVIDER: S-EPMC12474249 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature