Evaluation of the Dual Antiviral and Immunomodulatory Effects of <i>Phallus indusiatus</i> in a Feline Infectious Peritonitis Model Using PBMCs.

ABSTRACT: Feline infectious peritonitis (FIP) is a progressive and often fatal disease caused by a virulent biotype of feline coronavirus (FCoV). Although antiviral treatments are now available, relapse and resistance remain ongoing concerns. This study investigates the therapeutic potential of P. indusiatus, a medicinal mushroom, for its antiviral and anti-inflammatory activities against FIP. The main protease (FIPV M^pro) of feline infectious peritonitis virus (FIPV) was recombinantly expressed and purified to facilitate enzyme inhibition screening. P. indusiatus exhibited the strongest FIPV M^pro inhibitory activity among the 17 mushroom extracts tested (69.2%), showing a notable level of inhibition relative to standard antiviral agents such as lopinavir and rito

SUBMITTER: Hlaoperm C 

PROVIDER: S-EPMC12474325 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature