Clinical, Psychosocial, and Structural Factors Associated with the Detection of HIV Drug Resistance in Children Living with HIV in Kisumu, Kenya: Secondary Analysis of Data from the Opt4Kids Study.

ABSTRACT:

Background

HIV drug resistance (DR) mutations can compromise antiretroviral therapy (ART) success among children living with HIV (CLHIV). We conducted a secondary analysis using data from a randomized control trial for ART monitoring among CLHIV in Kisumu County, Kenya from 2019 to 2023, to assess clinical, psychosocial, and structural factors associated with HIV DR.

Methods

704 CLHIV were followed for 12+ months, with characteristics captured at enrollment and follow-up visits in the "parent" randomized-controlled-trial (of point-of-care plasma viral load testing and for viremias ≥ 1000 copies/mL HIV genotyping for DR vs. standard-of-care) and an observational "extension" substudy (of participants on a dolutegravir-containing ART with genotyping performed on viremic specime

SUBMITTER: Scallon AJ 

PROVIDER: S-EPMC12474375 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature