Proteomics Reveals Mechanisms of Metabolic Dysregulation in Soman Neurotoxicity.

ABSTRACT: Soman, an organophosphorus nerve agent, induces neurotoxicity primarily by inhibiting acetylcholinesterase, triggering a series of pathological events including cholinergic crisis, seizures, calcium overload, oxidative stress, mitochondrial dysfunction, and neuronal death. Nevertheless, the mechanisms underlying metabolic dysregulation-especially after repeated exposure-remain poorly characterized. To address this, we used SWATH-based proteomics to analyze changes in the hippocampal proteome following a repeated soman exposure regimen in a model of hippocampal injury. We identified 38 differentially expressed proteins, predominantly enriched in metabolic pathways. KEGG annotation indicated that these were mainly involved in carbohydrate, amino acid, and lipid metabolism, with specific role

SUBMITTER: Zong XX 

PROVIDER: S-EPMC12474405 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature