Metabolic Regulation of Influenza Vaccine Responses in Racially Diverse Hispanics.

ABSTRACT:

Background

Racial and ethnic differences in vaccine responses, particularly within Hispanic populations, remain underexplored. Disparities in immune function may be influenced by metabolic and inflammatory mechanisms.

Methods

The current study investigated humoral immune responses to influenza vaccination in a diverse cohort of Hispanic individuals from South Florida, encompassing both White and Black Hispanics. Antibody responses were assessed post-vaccination, and B cell phenotypes were analyzed to evaluate inflammatory and metabolic characteristics. In vitro experiments were conducted to determine whether blocking metabolic pathways could alter the inflammatory phenotype of B cells. Data were analyzed using an unpaired Student's t-test (two-tailed), and correlation

SUBMITTER: Frasca D 

PROVIDER: S-EPMC12474446 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature