Exocarpium Citri Grandis Attenuates Lipopolysaccharide-Induced Acute Liver Injury Through Suppression of Inflammatory, Apoptotic, Oxidative, and Ferroptotic Pathways.

ABSTRACT: This study aimed to elucidate the therapeutic mechanisms of Exocarpium Citri Grandis (ECG) against lipopolysaccharide (LPS)-induced acute liver injury (ALI) using an integrated approach combining network pharmacology and experimental validation. The chemical profile of ECG was characterized via UHPLC-Q-Exactive MS. Male C57BL/6J mice were employed to establish an LPS-induced ALI murine model for evaluating hepatoprotective effects of ECG. Serum AST/ALT levels, histopathology changes, and inflammatory, apoptotic, oxidative, and ferroptotic markers were analyzed. Additionally, network pharmacology was used to identify the targets and pathways of ECG, while molecular docking validated interactions between bioactive compounds and key regulatory molecules. ECG treatment significantly reduced se

SUBMITTER: Zhang G 

PROVIDER: S-EPMC12474559 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature