Cost-effectiveness of data driven personalised antibiotic dosing in critically ill patients with sepsis or septic shock.

ABSTRACT:

Purpose

This study provides an economic evaluation of bedside, data-driven, and model-informed precision dosing of antibiotics in comparison with usual care among critically ill patients with sepsis or septic shock.

Methods

This economic evaluation was conducted alongside an AutoKinetics randomized controlled trial. Effect measures included quality-adjusted life years (QALYs), mortality and pharmacokinetic target attainment. Costs were measured from a societal perspective. Missing data was multiply imputed, and bootstrapping was used to estimate statistical uncertainty. Differences in effects and costs were estimated using bivariate regression and used to calculate incremental cost-effectiveness ratios.

Results

Patients in the intervention group had higher costs (€42,

SUBMITTER: Broulikova HM 

PROVIDER: S-EPMC12474602 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature