Efficacy of naltrexone and bupropion combination in patients with binge eating disorder: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Binge Eating Disorder (BED) is a prevalent condition with limited evidence-based treatments. Naltrexone and Bupropion Combination (NB) targets neurobiological pathways implicated in BED. The Objective of this paper is to evaluate the efficacy of NB for BED in adults through a systematic review and meta-analysis.

Methods

Following PRISMA guidelines, we searched major databases and trial registries (up to Feb 2025) for randomized controlled trials (RCTs) comparing NB to placebo or usual care in adults with BED. The primary outcome was binge eating frequency; secondary outcomes included weight loss and BMI. Risk of bias (ROB2) and certainty of evidence (GRADE) were assessed. A fixed-effects meta-analysis was performed.

Results

Four RCTs (n = 444 participants) met

SUBMITTER: Roudbaraki SN 

PROVIDER: S-EPMC12474691 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature