Clinical presentation, predictive factors and management of patients with Nelson syndrome: a retrospective study.

ABSTRACT:

Background

Nelson syndrome (NS), or corticotroph tumor progression after bilateral adrenalectomy (CTP-BADX/NS), is a serious complication in patients with Cushing disease (CD) following BADX. Surgical tumor removal is the recommended treatment, though adjuvant therapies may be necessary.

Aim of the study

To evaluate clinical, radiological, and hormonal features of CD patients after BADX, identify risk factors for CTP-BADX/NS and assessed treatment outcome and cardio-metabolic complications.

Methods

Retrospective study of 30 patients (male/female: 9/21; median age at CD diagnosis: 33 years, IQR 27-42) who underwent BADX and had a minimum follow-up of 18 months. Data were collected at diagnosis and during follow-up (6, 24 months and last visit).

Results

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SUBMITTER: Mazzeo P 

PROVIDER: S-EPMC12474698 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature