Lag-structure in fMRI across Three Psychiatric Groups: State-dependency and Clinical-behavioral Correlates.

ABSTRACT: fMRI measures beyond zero-lag functional connectivity could serve as useful tools for understanding the distinct spatio-temporal dynamics characterizing psychiatric conditions. Therefore, the primary objective was to investigate whether and how state-dependence influences lag-structure in healthy controls (n = 95). Moreover, the study aimed to explore clinical-behavioral correlates of state-dependent lag-structure in three groups of psychiatric patients (35 ADHD, 38 Bipolar Disorder and 23 Schizophrenia patients, diagnosed according to DSM-IV-TR). Lag-structure was computed from cross-correlation coefficients in resting-state and stop-signal scans. Between and within-group differences were compared through non-parametric tests. Correlations with clinical-behavioral parameters were evaluate

SUBMITTER: Tarchi L 

PROVIDER: S-EPMC12474724 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature