Causal relationship between gut microbiota and pituitary neuroendocrine tumors: a bidirectional Mendelian randomization.

ABSTRACT:

Background

Previous observational studies have hinted at a connection between the gut microbiota and pituitary neuroendocrine tumors, yet the causal nature of this relationship remains uncertain.

Methods

We employed a bidirectional Mendelian randomization to explore the potential impact of gut microbiota on the susceptibility to developing pituitary neuroendocrine tumors. Our analysis included weighted median estimator, simple model, weighted model, inverse variance-weighted, and the MR-Egger regression method for estimating causal effects and conducting sensitivity analyses. Additionally, reverse Mendelian randomization analysis was conducted on bacteria identified as causally linked to pituitary neuroendocrine tumors.

Results

Causal relationships were identified bet

SUBMITTER: Wang W 

PROVIDER: S-EPMC12474756 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature