A new prognostic model for lung adenocarcinoma according propionate metabolism related genes: a comprehensive bioinformatic study.

ABSTRACT:

Background

The prognostic mechanisms of lung adenocarcinoma (LUAD) remain unclear, while the propionate metabolic pathway has been implicated in promoting tumor growth across multiple cancer types. This study aims to elucidate the mechanistic basis by which the propionate pathway influences LUAD progression at the genetic level.

Methods

The TCGA-LUAD cohort was retrieved from The Cancer Genome Atlas (TCGA), and LUAD-related datasets (GSE13213, GSE72079) were obtained from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) between LUAD and normal tissues were first identified, followed by intersection with propionate metabolism-related genes (PMRGs) to derive DE-PMRGs. After partitioning these genes into training and validation sets, a prognostic risk mo

SUBMITTER: Liu C 

PROVIDER: S-EPMC12474791 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature