Multi-omics analysis reveals the prognostic value and immunomodulatory role of CTSW in breast cancer.

ABSTRACT:

Background

The inherent complexity and biological heterogeneity of breast cancer pose substantial challenges to the development of effective personalized therapies. The exploration of novel biomarkers, particularly those linked to the tumor immune microenvironment (TME), presents promising opportunities. This study employed a multi-omics framework to investigate the potential regulatory role of cysteine proteases in breast cancer, aiming to identify and characterize novel prognostic markers and strategic therapeutic targets.

Methods

We employed a comprehensive in silico analysis utilizing transcriptomic, methylomic, quantitative trait locus, and genome-wide association studies data. Differentially expressed genes (DEGs) were identified using established statistical tools. Th

SUBMITTER: Liu X 

PROVIDER: S-EPMC12474806 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature