Phage receptor binding protein and Fc fragment fusion enhances phagocytosis of Y. enterocolitica.

ABSTRACT: Bacteriophage receptor binding proteins (RBPs) belong to a group of proteins that are components of the bacteriophage tail. RBPs are mainly responsible for recognizing receptors on the bacterial host surface and enabling infection and subsequent progeny phage multiplication. Our previous research suggested that recombinant tail fiber gp17 (TFPgp17) protein from Yersinia enterocolitica phage φYeO3-12 recognizes serotype O:3 with high specificity and could be used as a diagnostic tool. In this paper, we study the possibility of using modified TFPgp17 in fusion with IgG1 Fc immunoglobulin fragment (Fc_TFPgp17) to improve the efficacy of pathogen recognition by phagocytic cells, opsonization of bacterial cells, and then phagocytosis by the THP-1 macrophages and the HL-60 neutrophils. We demons

SUBMITTER: Filik-Matyjaszczyk K 

PROVIDER: S-EPMC12474815 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature