LncRNA DEPDC1-AS1 drives the progression of endometrial carcinoma by regulating miR-508-3p.

ABSTRACT:

Objective

Endometrial carcinoma (EC) ranks among the three most prevalent malignant tumors affecting the female reproductive system. DEPDC1-AS1 is a newly identified lncRNA, and its mechanism of action in EC remains to be explored.

Methods

100 hyperplasia and 100 EC patients were included. The abundance of DEPDC1-AS1, miR-508-3p, and SQSTM1 was quantified by qRT-PCR. Kaplan-Meier survival curve and Cox regression predicted prognostic factors. Pearson correlation was used to assess the relationships among the molecular markers. Cell proliferation was assessed with the CCK-8 assay, and migration/invasion with Transwell assays. The regulatory interactions were predicted by bioinformatics and validated through dual-luciferase reporter assays and co-transfection experiments.

R

SUBMITTER: Wang R 

PROVIDER: S-EPMC12474827 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature