Disulfidptosis OXSM serves as a potential prognostic biomarker and correlates with immune infiltrates in glioma.

ABSTRACT:

Background

Glioma, a common primary brain tumor arising from glial cells, presents significant therapeutic challenges due to its diverse and complex biological behavior. While disulfidptosis has recently emerged as a novel form of cell death, the role of disulfidptosis-related genes (DRGs) in glioma and their relationship with the tumor immune microenvironment remains poorly understood.

Methods

We analyzed DRGs expression patterns in glioma samples and their correlation with patient survival using data from TCGA, GEO, and CGGA databases. We employed ROC curve analysis to evaluate the diagnostic potential of individual DRGs and identify hub genes. We investigated the relationship between hub gene expression and immune cell infiltration through immune infiltration analysis. Ad

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12474845 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature