Exploration of effective biomarkers and infiltrating immune cells in metastatic colorectal cancer based on bioinformatics analysis.

ABSTRACT: Colorectal cancer (CRC) ranks as the third most prevalent malignancy globally and represents the second leading cause of cancer-related mortality worldwide. Metastatic colorectal cancer (mCRC) is clinically classified as an advanced-stage malignancy, characterized by therapeutic resistance and substantially diminished survival outcomes. The 5-year survival rate for mCRC is significantly lower than that for early-stage CRC. A multi-dimensional computational framework was implemented to dissect CRC transcriptomics. Gene expression profiles were systematically acquired from TCGA and GEO repositories. A series of data were then analyzed using ssGSEA algorithm, xCell algorithm, edgeR, limma, DAVID enrichment analysis, CytoHubba, ROC logistic regression and correlation analysis. Immune cell infi

SUBMITTER: Huang J 

PROVIDER: S-EPMC12474896 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature