High expression of Rex-orf-I and HBZ mRNAs and bronchiectasis in lung of HTLV-1A/C infected macaques.

ABSTRACT: HTLV-1 type-A rarely causes lung disease in humans, whereas HTLV-1 type-C is more frequently associated with respiratory failure and premature death. We investigated the genetic basis of HTLV-1C morbidity by constructing a chimeric HTLV-1A/C_oI-L encompassing the highly divergent type C orf-I. We demonstrate that systemic infectivity of HTLV-1A and HTLV-1A/C_oI-L is equivalent in macaques, but viral expression in lungs is significantly higher in HTLV-1A/C_oI-L infection. In addition, bronchoalveolar-lavage immune cell dynamics differs greatly with neutrophils and monocytes producing TNF-α in HTLV-1A/C_oI-L, but producing IL-10 in HTLV-1A infection. Animals infected with HTLV-1A/C_oI-L develops bronchiectasis at 10 months from infection, but

SUBMITTER: Sarkis S 

PROVIDER: S-EPMC12474910 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature